Abstract
Objective: To explore the effect of donepezil hydrochloride on cognitive function recovery of rat with Alzheimer’s disease and the positive expression of nitric oxide synthase and acetylcholinesterase (NOS and AchE) in the brain tissues of rats with Alzheimer's disease (AD).Methods: Forty SD (Sprague Dawley) rats were randomly classified into a model group, a treatment group, a control group, and a sham operation group. Each group had 10 rats. AD rat models were prepared with Aβ1-40. Donepezil hydrochloride was orally administered to rats in the treatment group two weeks after modeling. Rat recognition function was assessed. The positive expression of NOS and AchE in rat brain tissues was observed via immunohistochemistry after administration of 28 days.Results: Rat escape latency was significantly longer after modeling (p < 0.010). Compared to the model group, treatment group escape latency was significantly shortened and the difference was significant (p < 0.05). NOS and AchE positive expression mainly reflects in hippocampus region tissue. Compared with the control, and sham, operation groups, NOS positive expression decreased and AchE positive expression increased in the model group. The difference was statistically significant (p < 0.01). Compared with the model group, NOS expression in the treatment group increased and AchE expression decreased. The difference was significant (p < 0.01).Conclusion: Donepezil hydrochloride can promote AD rat cognitive function recovery. Its effects are also associated with increased NOS protein expression in hippocampus neuron cells in addition to specifically inhibiting the AchE activities.
Highlights
Alzeimer’s disease (AD) is a degenerative neurosis characterized mainly by cognitive and memorial dysfunctions
Its effects are associated with increased NOS protein expression in hippocampus neuron cells in addition to inhibiting the AchE activities
They were divided into a control group, sham operation group, model group, and a treatment group
Summary
Alzeimer’s disease (AD) is a degenerative neurosis characterized mainly by cognitive and memorial dysfunctions. It is a common dementia among the elderly. AD is the fourth most common elderly disease that causes death after cancer, heart and cerebrovascular diseases. It seriously reduces patient quality of life and is a heavy burden families and society. The association of learning and memory impairment of AD patients with the brain cholinergic dysfunction is known. Donepezil hydrochloride is a selective inhibitor of cholinesterase
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
