Abstract
Regional alveolar hypoxia produced by ventilation of a lung or lobe with hypoxic gas mixtures causes pulmonary vasoconstriction. This reduces the blood-flow to the hypoxic area and so minimizes the decrease in arterial PO2. It has now been shown that dobutamine and a number of inotropic, bronchodilator and inhalation anaesthetic drugs may reversibly inhibit the hypoxic pulmonary vasoconstrictor mechanism, thus increasing the blood flow to the hypoxic areas of lung so that there is a further decrease in arterial PO2. The purpose of the present experiments was to determine whether dobutamine could increase shunt by inhibiting pulmonary vasoconstriction in a collapsed left lower lobe of the dog.
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