Effect of discontinued oral antithrombotics during perioperative period of retinal detachment surgery

Abstract

Objective To observe the effect of discontinued oral antithrombotics during perioperative period of retinal detachment surgery on the efficacy and cardio-cerebral-vascular system. Methods The data of 46 eyes of 46 cases of early retinal detachment, who sustained oral prophylactic antithrombotics were analyzed retrospectively.All cases were divided into 2 groups randomly: group A, the total of 25 eyes suspended oral antithrombotics at 7 days before vitrectomy and continued oral antithrombotics at 7 days after vitrectomy. The group B, the total of 21 eyes did not suspend oral administration of antithrombotic agents before vitrectomy. All cases of two groups underwent vitrectomy under non-contact wild-angle viewing system and chandelier. The visual recovery, postoperative hemorrhage and effect on cardio-cerebral-vascular system were analyzed. Results BCVA of two groups were improved after vitrectomy (P=0.001, 0.000). The difference of intra- and post-operative hemorrhage was not significant between the two groups (P=0.410, 0.940). No cardiovascular or cerebrovascular event occurred during perioperative period. The waiting time for vitrectomy of group A was longer than that of group B (P=0.000), and the rate of silicone oil tamponade of group A was higher than that of group B (P=0.023). At the last follow-up, the visual acuity of group B was significantly better than that of group A (P=0.000). Conclusion The oral antithrombotics could not be suspended during perioperation of vitrectomy. Key words: Detachment, retinal; Vitrectomy; Antithrombotics; Hemorrhage; Visual acuity