Vitrectomy with silicone oil or perfluorinated propane tampomade for proliferative diabetic retinopathy

Abstract

Objective To observe the clinical efficacy of vitrectomy with silicone oil or C3F8 tamponade for proliferative diabetic retinopathy （PDR）. Methods 77 eyes of 60 patients with PDR who underwent vitreetomy from June 2010 to Dec. 2011 in author＇ s hospital were divided into two groups： silicone oil filling group and C3F8 tamponade group. There were no statistically significant differences in patients, age, sex and course of the disease between two groups （P 〉 0.05） . The visual acuity, intraoeular pressure （IOP）, retina and optic nerve were observed after surgery. Results The differences in visual acuity between two groups before and after operation were statistically significant （x^2 = 9. 20, P 〈 0. 05 ; x^2 = 9. 01, P 〈 0.05 ）. The difference in IOP after surgery between two groups was statistically significant （ Z = - 3.50, P 〈 0.05）. Of 41eyes in silicone oil group, the optic disc was pale in 5 eyes （ 12.20% ）, the color of optic disc became light in 3 eyes （ 7.32% ） , local retinal vascular occlusion occurred in 10 eyes （24.39%） and no retinal hemorrhage or detachment was found. Of 36 eyes in C3F8 tamponade group the gas was absorbed in all eyes, the color of optic disc became light in 3 eyes （8.33%）, retinal hemorrhage was in 5 eyes （ 13.88% ） , retinal redetaehment occurred in 2 eyes （5.55%） and no pale optic disc or local retinal vascular occlusion was found. Conclusion Vitrectomy with silicone oil tamponade is effective on PDR with uncontrollable lOP in fewer patients which may cause damage to vision function. In C3F8 tamponade group, no retinal redetachment or hemorrhage occurs and the visual function is better than that in silicone oil tamponade group. The right vitreous filler should be chosen for the PDR patients according to the retinal condition. The silicone oil should be removed as soon as possible after retinal reattachment to avoid optic nerve and retinal damage. Key words: Retinopathy, diabetic, proliferative ; Vitrectomy ; Silicone oil; Perflnorinated propane