Abstract
Diphenyl (DP), o-phenylphenol (OPP), 2-(4-thiazoyl) benzimidazole (TBZ), are used as fungicides for citrus fruits. The acute toxicity of these compounds has been established for whole animals. However, additional information as to the cytotoxic effect of these fungicides is required. The ciliated protozoan, Tetrahymena pyriformis, is a single cell organism easily grown in an axenic medium, and has nutritional requirements similal to those of higher animals. Therefore, T. pyriformis has been used as a tool for the determination of the toxicity of food colors and heavy metals. The authors report the toxicity of DP, OPP and TBZ using T. pyriformis as a model test system.
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