Effect of different types of triglycerides on patients with gastric cancer after radical operation

Abstract

Listen

Translate article

Objective To observethe effect of different types of triglycerides on nutritional status, hepatic and renal function and prognosis of patients with gastric cancer after radical operation. Methods Structural triglyceride (STG) group included 218 patients with venous infusion of structural triglyceride, while medium chain triglyceride and long chain triglyceride (MCT/LCT) group with venous infusion of lipofundin or lipovenoes had 194 patients. The indexes of nutrition [BMI, the score of nutrition risk screening 2002, serum total protein (TP), albumin (Alb), prealbumin], hepatic and renal function [aspartate amino transferase (AST), alanine aminotransferase (ALT), total bilirubin (TBIL), serum creatinine (Cr) and serum urea] and prognosis were analyzed. Results There were no statistically significant differences between the two groups in the general data (sex, age, BMI, NRS2002 score, operation time and blood loss during operation) (P=0.750, 0.266, 0.585, 0.555, 0.058, 0.134). TP, Alb, prealbumin, AST and ALT in the two groups showed a range of variations before operation and at postoperative day 3 and 7. The change indexes of STG group were respectively from (63.67±7.97) g/L, (37.23±5.57) g/L, (174.87±58.23) g/L, (28.59±16.10) U/L and (24.08±28.75) U/L to (62.51±6.98) g/L, (4.92±4.55) g/L, (144.60±41.54) g/L, (29.59±19.22) U/L and (25.96±21.73) U/L, while the change indexes of MCT/LCT group were respectively from (64.28±8.22) g/L, (37.55±5.42) g/L, (179.08±59.79) g/L, (29.11±15.39) U/L and (24.46±28.17) U/L to (61.00±6.56) g/L, (33.09±3.89) g/L, (132.10±42.39) g/L, (40.04±46.13) U/L and (35.30±41.87) U/L, which showed statistically significant difference between the two groups (P=0.024, 0.001, 0.009, 0.038, 0.030). There were no statistically significant differences (P=0.560, 0.242, 0.954) between the two groups in range of variations of TBIL, serum urea and Cr. There were significant difference (P=0.030, 0.023) between the two groups in anal exhaust time and changes in body weight after 7 days of operation. While there were no statistically significant differences (P=0.900, 0.250, 0.696) between the two groups in level of anastomotic leakage, wound infection rate and length of hospital stay. Conclusion In parenteral nutrition support structural triglyceride is more advantageous than medium chain triglyceride and long chain triglyceride for patients with gastric cancer after radical operation. The former can effectively accelerate the synthesis of metabolism, improve the nutritional status, protect the hepatic function, promote the recovery of gastrointestinal function and promote postoperative recovery of patients with gastric cancer. Key words: Gastric cancer; Parenteral nutrition; Structured triglyceride