Abstract
Effect of Different Exercise Mode and Ursolic Acid Supplementation on FNDC5 and UCP1 Gene Expression and Plasma Irisin in Rats
Highlights
The effect of regular physical activity on controlling and improving the disease and physiological capacities has been confirmed in previous studies
Regarding the changes observed in the present study, the interactive effect of Aerobic Training (AT) and Ursolic Acid (UA) supplementation may be more on brown adipose tissue production
Based on the specificity principle of training, it is likely that each variable can be influenced by a unique exercise mode
Summary
The effect of regular physical activity on controlling and improving the disease and physiological capacities has been confirmed in previous studies. The formation of brown adipose tissue is one of the important physiological signaling pathways. Non-shivering thermogenesis is the most important function of BAT This function is regulated by UCP1 (Uncoupling Protein) - known as thermogenin- located in the mitochondrial membrane. The signaling pathway for transformation of white adipose to BAT is influenced by physical activity involving the associations between irisin, FNDC5, and UCP1 gene expression [6,7]. The interactive effect of exercise mode and Ursolic Acid (UA) on the Brown Adipose Tissue (BAT) has not been well explored. The aim of the present study was to investigate the effect of 12-week Aerobic Training (AT), Resistance Training (RT), and High Intensity Interval Training (HIIT) along with UA supplementation on muscle FNDC5 and adipose tissue UCP1 gene expression as well as plasma irisin levels
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