Abstract
This study was carried out to investigate effects of oral administration of uranyl acetate on haematological parameters and liver enzyme. For this purpose, twenty females mature Albino rats were divided into four equal groups, control group G1 administrated distilled water, the other three groups administrated orally 50,75,100 mg/kg/b.w. /day of uranyl acetate. The route of administration was oral intubations for 10 weeks, for 14 days before mating with untreated males, as well as during pregnancy 3 weeks and lactation 5 weeks. At the end of the treatment blood samples were collected from mothers of rats. The results were obtained a significant P< 0.05 increase in the total WBC counts in groups G2,G3,G4 compared with control .A significant P<0.05 decrease in the lymphocytes and monocytes percentage in groups (G3,G4), while no significant decrease P>0.05 in G2 in the lymphocytes and monocytes percentage compared with control. And the results show significant P< 0.05 decrease in HB value in groups G3,G4, while no significant decrease P>0.05 in G2 in HB value compared with control. A significant P< 0.05 decrease was observed in total RBCs counts in groups G2,G3,G4 compared with control. No significant increase P>0.05 in GOT and GPT in groups G2 and G3 and significant P<0.05 increase in GOT and GPT activity in the serum in group G4 compared with control. No significant increase P>0.05 in CPK activity in groups G2,G3,G4 compared with control.
Highlights
Effect of different doses of uranyl acetate on some blood parameters and hepatic enzymesin females rats
The results show significant P< 0.05 decrease in HB value in groups G3,G4, while no significant decrease P>0.05 in G2 in HB value compared with control
Soluble uranium compounds were move into the blood within days or weeks, and will be absorbed in the blood and removed from it to other organs where theseparticles accumulate, their different biological effect appear which depending on their solubility and their biological half-life
Summary
Effect of different doses of uranyl acetate on some blood parameters and hepatic enzymesin females rats. The results were obtained a significant P< 0.05 increase in the total WBC counts in groups G2,G3,G4 compared with control.
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