Effect of different dosage combinations of nalbuphine and sufentanil on postoperative analgesia in patients undergoing abdominal hysterectomy surgeries

Abstract

Objective To observe the effect of different dosage combinations of nalbuphine and sufentanil on postoperative analgesia in patients undergoing abdominal hysterectomy surgeries. Methods One hundred and twenty-five patients scheduled for selective abdominal hysterectomy surgeries in Affiliated Huaian Hospital of Xuzhou Medical University from January 2015 to January 2018 were randomly divided into sufentanil 100 μg group (group S), sufentanil 75 μg combined with nalbuphine 25 mg group (group NS1), sufentanil 50 μg combined with nalbuphine 50 mg group (group NS2), sufentanil 25 μg combined with nalbuphine 75 mg group (group NS2) and nalbuphine 100 mg group (group N). The analgesic pump was set in the five groups as follows: loading dose 3 ml, continuous dose 2 ml/h, bolus dose 0.5 ml, lockout time 15 min, total volume 100 ml. The scores of incision pain and visceral pain of 4, 8, 12, 24 and 36 h of NRS, Ramasy sedation score, number of analgesia pump compressions and incidence of adverse reactions were recorded respectively in patients after operation. Results Compared with those in group NS3 and group N, the scores of incision pain of NRS were significantly lower 4 and 8 h after surgery in group S, group NS1 and group NS2 (P < 0.05). Compared with those in group S and group NS1, the scores of visceral pain of NRS was significantly lower at the time 4 and 8 h after surgery in group NS2, group NS3 and group N (P < 0.05). Compared with group NS2, the number of analgesia pump compression was significantly higher in group S, group NS1, group NS3 and group N, (3.0 ± 1.7), (3.0 ± 1.5), (2.9 ± 1.8), (2.9 ± 1.6) times vs. (1.7 ± 1.0) times, P < 0.05. Compared with those in group S, the nausea and vomiting were lower in group NS2, group NS3 and group N, nausea: 8% (2/25) , 8%(2/25), 4%(1/25) vs. 20% (5/25), vomiting: 8% (2/25), 8% (2/25), 8% (2/25) vs. 20% (5/25), P < 0.05. Conclusions The optimal ratio of nalbuphine to sufentanil in postoperative analgesia after abdominal hysterectomy surgeries was 1∶1, because it has good analgesic effect and low incidence of adverse reactions. Key words: Nalbuphine; Sufentanil; Hysterectomy; Postoperative analgesia