Abstract
The effect of dietary triiodothyronine (T 3) supplementation (0, 0.01, 0.1, and 1.0 ppm of T 3) on the mixed lymphocyte response (MLR) was examined in MHC-matched young Cornell K and sex-linked dwarf (SLD) strain cockerels at ages 6, 9, and 12 weeks. At all ages, MLR in SLD strain cockerels was significantly lower than in the K strain. Supplementation of 6-week-old cockerels with 0.01 and 0.1 ppm of T 3 tended to decrease MLR in both strains, whereas the highest does of T 3 had the opposite effect in the K strain and no effect in the SLD strain compared to the control. No significant effects of T 3 on MLR were observed in 9-week-old cockerels. A significant main treatment effect of T 3 on MLR was observed in 12-week-old cockerels. At this age dietary T 3 decreased MLR in both strains. These results show that allo-aggression, a functional parameter of cell-mediated immunity, can be affected by non-MHC controlled strain differences and by the iodothyronine state of these strains.
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