Abstract
The effect of dietary nitrate on endogenous nitrosation of a therapeutic dose of piperazine has been described in five human volunteers who acted as their own controls. The urinary excretion of endogenously formed N-nitrosomonopiperazine (MNPz) ranged between 9.2 and 80.1 μg/24 h on a normal uncontrolled diet which increased from 25.7 to 163.7 μg/24 h when the diet was supplemented with 250 mg nitrate. The corresponding urinary nitrate was 63.0 – 122.7 mg/24 h and 119.2 – 322.0 mg/24 h, respectively. The dinitroso derivative of piperazine was detected only in trace amounts and no detectable increase in its excretion was observed during high nitrate exposure. The unchanged piperazine (range 294 – 784 mg/24 h) in urine showed a decrease under high nitrate regimen (range 185 – 399 mg/24 h).
Published Version
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