Abstract

The objective of this study was to determine the effect of dietary mannoheptulose (MH) on glucose and energy metabolism in adult male neutered Labrador Retrievers (N = 6, 5.4 y). This study was designed as a cross‐over with each dog receiving both dietary treatments, control (CON) and MH (200 mg/kg), in random order. Fasting and post‐prandial respiratory quotient (RQ) and energy expenditure (EE) were determined by indirect calorimetry (d 16). Glucose kinetics were assessed during fasting and repeated meal feeding using indirect calorimetry and a primed continuous infusion of U‐13C‐glucose (d 18). A fasting biceps femoris muscle sample was obtained (d 21/22) to determine protein content of phosphorylated and total adenosine monophosphate‐activated protein kinase (AMPK) and acetyl CoA carboxylase (ACC). Diet did not affect plasma glucose, insulin, FFA or glucose turnover during fasting or repeated meal feeding. There were no diet‐related differences in glucose oxidation or energy metabolism in the fed state. However, there were trends for MH to increase RQ (p=0.14) and glucose oxidation (p=0.16) and to lower the ratio of phosphorylated to total AMPK protein content (P=0.08) during fasting. These findings suggest daily MH feeding may affect carbohydrate utilization during fasting.Grant Funding Source: Procter and Gamble Pet Care

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.