Abstract
The effect on carcinogenesis of diets varying in types and levels of oils, including safflower oil and high-oleic safflower oil, was examined. In 1,2-dimethylhydrazine (DMH)-treated ICR mice, the colon cancer incidence in animals fed a high-fat diet of high-oleic safflower oil (HO) was indistinguishable from that in mice fed low-fat diets of safflower and high-oleic safflower oils. In contrast, animals fed a high amount of normal safflower oil (HS) in their diet had significantly higher tumor incidence—mostly adenocarcinomas—when compared with other groups. The linoleic acid content in the liver and colon phospholipids was significantly increased in the HS diet group as compared with the other three groups. However, the amount of arachidonic acid was not increased. The long-chain fatty acid 24:1(n-9) content in the colon sphingomyelin fraction of HS diet mice was significantly lower than in other groups. In N-nitrosomethylurea (NMU)-treated F344 rats, the HS diet accelerated the promotion of NMU-induced breast cancer, while the HO diet did not. The results of these studies suggest that oleic acid does not enhance colon and mammary carcinogenesis, even in a high-fat diet. A high-fat diet rich in linoleic acid, in contrast, promoted colon and mammary cancer.
Published Version
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