Abstract
Mycotoxins contribute great adverse health concerns, especially on liver and kidney. The current study aimed to investigate the possible protective effect of dietary curcumin on hepatorenal aflatoxicosis in mice. Thirty-two male albino mice 18-20 g were divided into 4 groups. Group I, is the control group received basal diet. Group II, received a basal diet with 2% curcumin. Group III, given a basal diet with added AFs (5 µg/kg). Group IV, co-administered AFs and curcumin at the same previous doses. All treatments continued for 4 weeks. Liver and kidney weights, as well as food conversion ratio (FCR), were determined. The serum levels of Superoxide dismutase (SOD), total antioxidant capacity (TAC), Malondialdehyde (MDA) and Interleukin-6 (IL-6) were estimated. Serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), albumin and creatinine were estimated. Histopathological examination to liver and kidney was performed. AFs significantly increased FCR and liver weight than control. The levels of SOD and TAC significantly reduced in-group III while MDA and IL-6 increased than control. The levels of AST, ALT and creatinine were significantly (P<0.05) increased in AFs group meanwhile albumin was significantly reduced than control. Hepatic and renal tissue showed congestion, lymphocytic infiltrations and other retrogressive changes. The co-administration of curcumin with AFs significantly ameliorated the AFs induced adverse effects. Curcumin possesses antioxidant effect that ameliorated aflatoxicosis adverse effects on the kidney and liver.
Highlights
The contamination of feedstuffs with toxic materials during processing or storage have constituted a drastic problem for both animal and human health (Devendran and Balasubramanian, 2011)
Concerning food intake and body weight gain both were significantly reduced in control curcumin group than control
The current study investigated the effect of dietary curcumin 2% to counteract AFs in albino male mice model
Summary
The contamination of feedstuffs with toxic materials during processing or storage have constituted a drastic problem for both animal and human health (Devendran and Balasubramanian, 2011). Among these toxic materials mycotoxins are existing which are toxins produced by fungi and contaminate feed stuffs (Glenn, 2007). Aflatoxins are incriminated in the production of several disorders in the normal physiological functions such as development, growth, metabolism, immunity and reproduction are altered These disorders include a reduction in efficiency of feed utilization, body weight loss, reproductive capacities and immune impairments (Pestka, 2007). All these perturbations lead to economic losses (Wu, 2006)
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