Effect of diet on the response in rats to lead acetate given orally or in the drinking water

Abstract

Liver lead levels were higher for rats that were orally dosed with 100 mg lead acetate/kg body wt and fed a semipurified diet than those fed a pelleted diet. The activities of delta-aminolevulinic acid dehydratase in blood were decreased in the group given 10 micrograms lead acetate/mL in their drinking water and fed the semipurified diet, but not in the blood from the group treated with lead and fed the pelleted diet. The levels of glutathione in the liver decreased in response to lead acetate in the drinking water of rats fed the semipurified diet, but not in the livers from the group fed the pelleted diet and treated with lead. The levels of lead in the kidneys were higher in the group given lead acetate in their drinking water and fed the semipurified diet than in the lead treated group fed the pelleted diet. Rats dosed orally with lead or given lead in the drinking water and fed the semipurified diet were more sensitive to lead treatment than those fed the pelleted diet.