Effect of dexmedetomidine combined with seven isoflurane for elderly patients with rectal cancer radical operation on recovery quality

Abstract

Objective To investigate the effects of dexmedetomidine combined with sevoflurane on elderly patients with postoperative recovery quality. Methods Selected 60 cases of abdominal rectal cancer resection for elderly patients,which were ASA I or II,were randomly divided into two groups by a random number table method,while each groupincluded 30 cases:the control group(group N)and the dexmedetomidine group(group D).Before the induction of anesthesia,group D vein was injected with micro pump(more than 10 min) of dexmedetomidine 1μg/kg (which was formulated with physiological saline as 4μg/mL),and then was given to maintain the dexmedetomidine 0.5μg/h and N group was injected with micro pump of the same volume of normal saline.The two groups of anesthesia were same,by which the static inhalation of composite general anesthesia.Observation were recorded before induction of anesthesia(T0),given dexmedetomidine(TI),after intubation 1 min(T1),5 min(T2),drawing tube immediately(T3),extubation after 5min(T4),30min(T5)the time of HR,BP,Sp O2,BIS;propofol and remifentanil dosage,operative time,operation time,a nesthesia time,recovery time,drawing tube time,extubation after Ramsay Sedation score,pain score,patient satisfaction and adverse reactions were recorded. Results In T3 period,the changes of HR (82±14)times/min,SBP(130±8)mm Hg,DBP(85±13)mm Hg in group N were more obvious than(70±12) timse/min,SBP(121±7)mm Hg,DBP(79±9)mm Hg in group D,the difference between the two groups had statistical significance(t= 6.28,4.63,2.08,all P 0.05).In group N,postoperative restlessness in 8 cases,nausea and vomiting in 10 cases,chills in 9 cases,which were significantly higher than 2 cases,2 cases,2 cases in group D(χ2= 4.32,6.67,5.45,all P< 0.05).At the same time,the satisfaction score of patient in group D(3.0±0.3) point,which was significant higher than(2.7±0.5)points in group N(t= 1.88,P<0.05). Conclusion Dexmedetomidine detomidine composite sevoflurane anesthesia can improve the postoperative recovery quality of elderly patients with rectal cancer radical surgery. Key words: Rectal Carcinoma; Dexmedetomidine; Seven halothane; Aged