Abstract
Objective To explore the effect of deep brain stimulation(DBS)in nucleus accumbens on learning and memory ability of morphine dependence rats.Methods According to stereotaxic atlas of the rat brain,DBS electrodes were implanted in rats bilateral nucleus accumbens,then Morris water maze test were carried out on the tenth day of morphine injection and the first day after DBS.Results The average time of reaching platform of three groups was different significantly before DBS(F=7.49,P=0.0077);and that of morphine addiction group wag longer than saline control group(P＜0.01).While after DBS,there was also significantly different(F=7.76,P=0.0069);the time had significant difference between DBS group and fake stimulation group(P=0.014),not saline control group(P=0.43);and fake stimulation group compared with saline control group(P=0.0056).The time of crossing the platform quadrant(Ⅱ)showed significant difference between saline control group and morphine addiction group(P<0.01);and the saline control group(48.53±2.29),compared with fake stimulotion group(20.74±2.13)(P=0.001),DBS group(38.34±1.68)(P=0.062).Conclusion DBS can improve the learning and memory ability impaired by morphine in rats. Key words: Deep brain stimulation; Nucleus accumbens; Morphine; Morris water maze
Published Version
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