Abstract
Purpose: Interactions between tear proteins and the interface of contact lenses (CL) can be complex and can influence CL wear success. Tear proteins, including lysozyme, function to maintain the balance of ocular surface homeostasis, evidenced by research of its conformation relative to stabilizing the tear film, its lubricating properties, and the potential impact of denatured lysozyme to corneal cells. A novel silicone hydrogel daily disposable CL, kalifilcon A, has integrated multiple moisturizers infused into the lens material to help stabilize the tear film. This in vitro study investigates the ability of daily disposable CL solutions to stabilize lysozyme in its native state.
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