Abstract
Young adult CFW mice, injected with sheep erythrocytes, were treated with cyclophosphamide and sacrificed at different times. The activity of acid phosphatase and for non-specific esterase was measured by semi-quantitative methods in smears prepared from cell suspension of draining lymph node. In cyclophosphamide-treated mice was noted a significant decrease in acid phosphatase activity in lymphoid cells, expressed both as average activity in single lymphoid cell and a decrease in proportion of cells exhibiting enzyme activity. Also a shortterm decrease was observed in activity of non-specific esterase caused both by disappearance of highly active large lymphoid and blast cells as well as decrease in percentage of enzyme-positive small lymphocytes.
Published Version
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