Abstract
Lippia graveolens (Kunth) essential oil (EO) contains the bioactive compounds carvacrol and thymol in different concentrations according to their chemotype. We evaluated the effect of the essential oil chemical composition, and different cyclodextrins (CD), β- and γ, on the microencapsulation process and its efficiency. Complex formation of L. graveolens EO with β-CD and γ-CD was determined by Scanning Electron Microscopy, X-Ray Diffraction, Thermogravimetric Analysis, and Fourier Transform Infrared Spectroscopy. Carvacrol and thymol concentrations in the γ-CD complexes were higher than in the β-CD complexes, as demonstrated by Gas Chromatography analysis. After 14 days of storage, carvacrol concentration in the β-CD complex remained similar to the initial values; while in the γ-CD complex the concentration was significantly reduced. In the case of thymol concentrations, no significant losses were observed after storage in the complexes obtained with β-CD or γ-CD. Our results confirmed that the microencapsulation of L. graveolens EO with CDs retained the bioactive compounds, carvacrol and thymol. Based on the amount of bioactive terpenes in these complexes and their relative stability, the best combinations to be used as delivery systems were the complexes formed between chemotypes thymol- γ-cyclodextrin and carvacrol-β-cyclodextrin.
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