Abstract
Liquid-liquid phase separation of proteins is a fast growing area of biophysical inquiry due to the role it plays in the formation of membraneless organelles, disease-associated protein aggregation, and disordered protein domains in signaling. Examining these processes in the context of entropy and enthalpy changes is necessary to establish a thermodynamic foundation with which to understand phase transitions. Our previous work probed the phase separation of glycine-rich pentapeptides and found that a loss of conformational entropy upon phase separation is compensated for by a decrease in peptide interaction enthalpy.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
