Abstract
The action of cortisone on bone collagen and collagenolytic activity has been investigated. Rats were injected subcutaneously with cortisone acetate and the collagen content, the incorporation of 14C-proline into 14C-hydroxy-proline, and the collagenolytic activity of the control and cortisone-treated rat bones were determined. The effect of cortisone on bone collagenolytic enzyme was also assayed.It was observed that cortisone administration caused a reduction of the collagen content and a decreased incorporation of 14C-proline into 14C-hydroxyproline. The collagenolytic activity of the bone was reduced and cortisone has also an inhibitory effect on bone collagenolytic enzyme. These results suggest that cortisone not only inhibits the biosynthesis of bone collagen but diminishes the collagenolytic activity of rat bone.Cortisone and bone collagenolytic activity. Cortisone is known to affect the metabolism of several constituents of connective tissue (1, 2) and it has been repotred that the re-sorption of ...
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