Abstract
AbstractKivirikko, K. I. and O. Laitinen. Effect of cortisone on the hydroxyproline in the serum and urine of young rats. Acta physiol. scand. 1965. 64. 356–360. –The effect of cortisone on the metabolism of collagen was studied by analysing the concentration of free hydroxyproline in the serum and the excretion of free and total hydroxyproline in the urine of 2‐ and 7‐month‐old rats. The younger rats, weighing 150 g at the beginning of the experiment, received 3 mg and the older rats, weighing 310 g at the beginning of the experiment, 6 mg of cortisone acetate daily. In the 2‐month‐old rats the concentration of free hydroxyproline in the serum and the excretion of free and total hydroxyproline in the urine decreased significantly after the administration of cortisone. By contrast, in the 7‐month‐old rats, which had considerably lower basal values than the 2‐month‐old rats, no changes or only very slight decreases were observed after the administration of cortisone. It is suggested that the decrease in the values observed after the administration of cortisone was due to a decreased content of soluble collagen fractions in the tissues. Probably the smallness of the changes in the 7‐month‐old rats was because a considerably smaller proportion of the hydroxyproline in the serum and urine of these older rats was derived from soluble collagen fractions.
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