Abstract
SummaryGuinea pigs were used throughout this study. The number of eosinophils in the blood of males was significantly lower than that in females. Cortisone reduced the number of eosinophils in the blood of males and females. ACTH produced a pronounced eosinopenia in males and nonpregnant females. Pregnancy abolished the eosinopenic effect of ACTH. Neither cortisone nor ACTH had any effect upon the degree of anaphylactic shock produced in guinea pigs by the intravenous injection of the agent to which the animals had been sensitized.
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