Effect of copolymer ratio on hydrolytic degradation of poly(lactide-co-glycolide) from drug eluting coronary stents

Abstract

The in vitro hydrolytic degradation behavior of poly( d, l-lactide-co-glycolide) (PLGA) has been systematically investigated from the drug eluting coronary stents with respect to different copolymer compositions. The drug–polymer coated stents were incubated in phosphate buffer saline (pH 7.4) at 37 °C and 120 rpm up to 12 months to facilitate hydrolytic degradation. Gel permeable chromatography, differential scanning calorimetry and scanning electron microscopy were employed to characterize their degradation profiles. The study supports the bulk degradation behavior for PLGA from coated stents. Molecular weight of polymer decreased immediately after immersion in PBS but mass loss was not observed during first few days. The rate of hydrolytic degradation was influenced by copolymer ratio, i.e., degradation of 50:50 PLGA was fastest followed by 65:35 PLGA and 75:25 PLGA. The drug release from PLGA coated stent followed biphasic pattern which was governed by surface dissolution and diffusion of drug rather than polymer degradation.