Abstract
Objective To investigate and analyze the effect of conventional platinum chemotherapy combined with Erchen decoction in the treatment of non-small cell lung cancer(NSCLC)with phlegm syndrome on the expression levels of insulin-like growth factor-binding protein-3(IGFBP-3)and vascular endothelial growth factor(VEGF). Methods A retrospective study was performed on 92 cases of patients with NSCLC with phlegm syndrome who were admitted from January 2015 to January 2017.Patients were randomly divided into the conventional treatment group and combined treatment group, with 46 cases in each group.In the conventional treatment group, 25 males and 21 females were aged(61.23±3.45)years, ranging from 52 to 77 years old.In the combined treatment group, 26 males and 20 females were aged(60.19±4.02)years, ranging from 51 to 73 years old.Clinical effect, serum IGFBP-3, VEGF expression level, quality of life, 2-year survival rate, recurrence rate and safety were compared between the two groups. Results After treatment, the effective rate of the combined treatment group [45.6%(21/46)] was significantly higher than that of the conventional treatment group[32.6%(15/46)]. After treatment, the serum IGFBP-3 [(1 925.41±450.82)μg/L] in the combined treatment group was higher than that in the conventional treatment group[(1 560.41±349.91)μg/L], and the VEGF level [(1 778.61±400.21)pg/ml] was lower than that in the conventional treatment group[(2 175.21±543.20)pg/ml], and the difference was statistically significant(P 0.05). Conclusion Conventional platinum-based chemotherapy combined with Erchen decoction can significantly improve the treatment of non-small cell lung cancer with sputum syndrome.It can regulate the expression levels of serum IGFBP-3 and VEGF, improve the quality of life, and also has a certain auxiliary effect in prolonging the survival time. Key words: Conventional platinum chemotherapy; Erchen decoction; Sputum syndrome non-small cell lung cancer; Insulin-like growth factor binding protein-3; Vascular endothelial growth factor; Survival rate
Published Version
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