Effect of compounds identified in the active fraction of pericampylus glaucus on blood glucose and lipid profiles in streptozotocin-induced diabetic rats

Abstract

Objective The present study was designed to determine the effect of compounds identified in the active fraction of Pericampylus glaucus on blood glucose and lipid profiles in streptozotocin (STZ)-induced diabetic rats. Materials and methods Initially, the antidiabetic activity of petroleum ether, n-hexane, chloroform, and ethanolic extracts of P. glaucus was evaluated in STZ-induced diabetic rats at a dose of 400 mg/kg body weight. Then, the potential extract was fractionated by different solvent systems to obtain various fractions. Next, fractions were investigated again at a dose of 100 mg/kg body weight to find the active fraction. The active fraction was examined using STZ-induced diabetic rats for 21 days. The blood glucose levels were observed weekly and various biochemical parameters were determined on the day the rats were killed. Results The active fraction was subjected to gas chromatography mass spectrometry to find the compounds present in the active fraction of ethanolic extract of P. glaucus. The ethanolic extract was noted to have significant (P Conclusion The present study confirmed the presence of compounds identified in P. glaucus responsible for the attenuation of blood glucose and lipid parameters.