Abstract
BackgroundRecent studies have reported that herbal extracts may have some protective effect against the complications of diabetes mellitus. This study aimed to investigate the effects of Achillea millefolium hydroalcoholic extract in comparison to metformin on liver damage, lipid abnormality, and glycemic control in diabetic rats.MethodsRats were randomly assigned to 7 groups of 10 animals. Diabetes was induced by injection of streptozotocin (STZ) to 4 groups of rats. Three groups of diabetic rats were given 250 mg/kg/day metformin, 25 mg/kg/day Achillea millefolium hydroalcoholic extract, or 100 mg/kg/day of this extract. Two non-diabetic groups were also given either 25 mg/kg/day or 100 mg/kg/day Achillea millefolium extract. Normal control and diabetic control rats received 1 mL/day of normal saline. Treatments were administered through oral gavage for 28 days. At the end, rats were anesthetized with ether and their serum samples were separated in order to measure blood glucose, serum total protein, lipids, and liver enzymes.ResultsThere was a significant reduction in blood glucose, serum liver enzymes, triglycerides, and total- and LDL-cholesterol levels of the Achillea millefolium extract-treated groups compared to the other groups. In addition, there was a significant increment in body weight and HDL-cholesterol serum level in the Achillea millefolium-treated groups.ConclusionAchillea millefolium extract compared to metformin reduces lipid abnormality, blood glucose and liver enzymes in STZ-induced diabetic rats. Future clinical studies are warranted to confirm our experimental findings in humans.
Highlights
Recent studies have reported that herbal extracts may have some protective effect against the complications of diabetes mellitus
To a better understanding of molecular mechanisms of Achillea extract against metabolic abnormalities, this study aimed to investigate the effects of hydro-alcoholic extract of Achillea millefolium on lipid profile, blood glucose, body weight, and serum liver enzymes in streptozotocin (STZ)induced diabetic rats
Effect of Achillea millefolium on body weight There was a significant increase in body weight in healthy groups receiving Achillea millefolium
Summary
Recent studies have reported that herbal extracts may have some protective effect against the complications of diabetes mellitus. Herbal drugs are used as alternatives for routine drugs for diabetic patients [3] One of these herbal drugs is derived from Achillea millefolium belonging to the Asteraceae family and possessed a variety of pharmaceutical benefits, traditionally used in the amelioration of diabetes, high blood pressure, renal stones, muscle pain, acne, and bleeding [3, 4]. These effects are attributed to essential compounds in Achillea species such as tanene, terepen, acetylen, lacton and razin. It is reported that the plant Achillea may counteract the side effects of drugs and improve the potency of therapeutic procedures [5]
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