Effect of compound glycyrrhizin on levels of cytokines and cellular immune function in children with Henoch-Schonlein purpura

Abstract

Objective To explore the effect of compound glycyrrhizin on the cellular immune function and the levels of cytokines in serum of children with Henoch-Schonlein purpura. Methods 60 cases of allergic purpura were selected and randomly divided into observation group and control group.The control group were treated with symptomatic treatment and routine nursing care, the observation group was treated with compound glycyrrhizin.The improvement of symptoms of the two groups, Treg cell and Th17 cell positive rates, as well as the levels of IL-10, IL-12 and IL-1β beta were observed. Results After analysis and comparison, the effective rates of rash, abdominal pain and joint symptoms in the observation group were 93.30%, 87.70% and 76.70% respectively, which were significantly higher than 57.60%, 56.70% and 50.00% in the control group, the differences were statistically significant (χ2=5.455, 6.648, 3.890, all P<0.05). The proportions of Treg cells and Th17 cells in peripheral blood after treatment in the observation group were 7.77% and 6.14%, which were significantly higher than those of the control group (0.60% and 0.46%), and the differences were statistically significant (t=2.391, 2.355, all P<0.05). After treatment, the levels of IL-10, IL-12 and IL-1β beta in the observation group were (46.26±6.37)pg/mL, (117.36±12.76)pg/mL, (6.69±1.23)pg/mL, which were higher than those of the control group (29.43±4.77)pg/mL, (89.46±8.38)pg/mL, (4.23±1.06)pg/mL, the differences were statistically significant (t=11.583, 10.010, 8.298, all P<0.05). Conclusion The effect of compound glycyrrhizin on the cellular immune function and the level of cytokines in serum of children with Henoch-Schonlein purpura is good. Key words: Compound glycyrrhizin; Henoch-Schonlein purpura; Cellular immunity; Cytokines