Abstract
Breast cancer is the most commonly diagnosed cancer and the major cause of cancer-related death among females. Studies on natural compounds used alone or in combination with chemotherapeutic agents proved their efficacy to treat and prevent cancer. Hesperidin, Piperine, and Bee venom displayed anti-oxidant and anti‑cancer activity against various types of cancers and cell lines and can be used in combination with Tamoxifen with the aim to decrease cytotoxicity profile. In-vivo study of Piperine (Pip), Bee venom (BV) and hesperidin (Hes) as a single treatment or in combination with/without tamoxifen indicated low hepato-nephrotoxicity and hepato-nephroprotective against tamoxifen-treated and untreated xenograft MCF-7 induced breast cancer. Serum ALT, AST, ALP activities and creatinine, and urea level were elevated. MDA level was increased with a marked reduction in SOD activity in the untreated xenograft MCF-7 induced breast cancer. Treatments for these natural products improve these parameters. It could be concluded that alone or in combination with/ without Tamoxifen clarified a modulatory role against breast cancer.
Highlights
IntroductionThe incidence and mortality of breast cancer are 43.3 and 12.9 per million in women respectively, which is in the top of all female related cancers [1]
Effect of treatments with tamoxifen, hesperidin, piperine, and bee venom on liver function (ALT, AST, alkaline phosphatase (ALP)) The serum activities of liver enzymes (AST, ALT and ALP were found to be significantly higher in xerographic MCF-7 injected rats when compared to normal control animals (Table 1, Fig. 1)
Toxicity study revealed a low level of or improvement of hepatic and nephrotoxicity of pip, Bee venom (BV) and Hes the in case of single or in combination therapy with/without as compared with untreated breast cancer group which indicated by lower levels of AST, ALT, ALP, urea, and creatinine, especially in four combination treatment
Summary
The incidence and mortality of breast cancer are 43.3 and 12.9 per million in women respectively, which is in the top of all female related cancers [1]. Breast cancer is controlled by surgery, chemotherapy, radiotherapy and frequently supported by hormone therapies [2]. Even though treatment strategies of breast cancer have been developed, current treatments of breast cancer are still not enough to fundamentally treat this disease due to; side effects, drug resistance and non-specificity [3]. This situation pushes researcher to keep moving to discover new promising anticancer drugs.
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