Year-end Sale % OFF 
Abstract
Oral administration of bovine collagen peptide (CP) combined with calcium citrate (CC) has been found to inhibit bone loss in ovariectomized rats. However, the protective effects of CP and CP–CC against bone loss have not been investigated in a tail-suspension simulated microgravity (SMG) rat model. Adult Sprague-Dawley rats (n = 40) were randomly divided into five groups (n = 8): a control group with normal gravity, a SMG control group, and three SMG groups that underwent once-daily gastric gavage with CP (750 mg/kg body weight), CC (75 mg/kg body weight) or CP–CC (750 and 75 mg/kg body weight, respectively) for 28 days. After sacrifice, the femurs were analyzed by dual-energy X-ray absorptiometry, three-point bending mechanical tests, microcomputed tomography, and serum bone metabolic markers. Neither CP nor CP–CC treatment significantly inhibited bone loss in SMG rats, as assessed by dual-energy X-ray absorptiometry and three-point bending mechanical tests. However, both CP and CP–CC treatment were associated with partial prevention of the hind limb unloading-induced deterioration of bone microarchitecture, as demonstrated by improvements in trabecular number and trabecular separation. CP–CC treatment increased serum osteocalcin levels. Dietary supplementation with CP or CP–CC may represent an adjunct strategy to reduce the risk of fracture in astronauts.
Highlights
The development and maintenance of bone structure depends on mechanical stimulation.Numerous studies have demonstrated that mechanical loading promotes bone formation, whereas the absence of mechanical stimulation decreases bone mass [1]
Oral administration of collagen peptide (CP) or CP–calcium citrate (CC) improved had reductions in bone mineral density (3.29%, p = 0.029), bone volume per total volume (BV/TV) (91.48%, p = 0.026), Tb.N (41.12%, bone microarchitecture and density, with thicker trabecular bone, indicating that bone loss was p = 0.006), and Tb.Th (20.63%, p = 0.005)
Discussion administrated 750 mg/kg bovine collagen peptide combined with 75 mg/kg calcium citrate daily; CP, Bone is a complex tissue
Summary
Numerous studies have demonstrated that mechanical loading promotes bone formation, whereas the absence of mechanical stimulation decreases bone mass [1]. Astronauts experience microgravity that leads to serious physiological changes, one of the most prominent being bone loss, which increases fracture risk [2]. Drug intervention is not routinely used in space flight and exercise has been combined with nutrition improvement. Because of the lack of mechanical load or duration of space flight, osteoblast stimulation is insufficient to maintain bone mass [4]. This has led to a focus on pharmaceutical interventions such as osteoporosis drugs, but their potential to prevent bone loss in space remains to be clarified.
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
