Abstract
AbstractA gastro retentive drug‐delivery system for nifedipine was developed by incorporating the drug in cellulose acetate hollow microspheres capable of floating on the gastric and intestinal fluid. The microspheres were prepared by solvent diffusion–evaporation technique in the presence of coexcipients like polyethylene glycol, dibutyl phthalate, and poly(ε‐caprolactone) using ethyl acetate as a dispersing solvent. Size of the microparticles depends upon the type and concentration of the excipient used. Microparticles exhibited floating properties on the simulated‐gastric fluid for >12 h. Their percentage buoyancy followed the rank order of: blank (no coexcipients) > dibutyl phthalate > polyethylene glycol > poly(ε‐caprolactone) after 15 h of floating. Release of nifedepine was enhanced by the addition of coexcipients. The drug release followed non‐Fickian transport in almost all formulations. © 2006 Wiley Periodicals, Inc. J Appl Polym Sci 100: 486–494, 2006
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