Effect of clopidogrel combined with rosuvastatin on vascular endothelial function and cardiac function in patients with coronary heart disease

Abstract

Objective To investigate the effect of clopidogrel combined with rosuvastatin on vascular endothelial function and cardiac function in patients with coronary heart disease (CHD). Methods 106 CHD patients treated in our hospital from March 2016 to May 2017 were selected, and were divided into two groups according to the random number table, with 53 cases in each group. The control group was treated with clopidogrel, while the observation group was treated with rosuvastatin based on the control group. The curative effect, vascular endothelial function, cardiac function, and adverse reactions were compared between the two groups. Results The total effective rate of the observation group [94.34% (50/53)] was higher than that of the control group [77.36% (41/53)] (P<0.05). After the treatment, the level of NO in the observation group was higher than that in the control group, but the levels of AngII and VEGF in the observation group were lower than those in the control group (P<0.05). After the treatment, LVEDV and LVESV in the observation group were lower than those in the control group, but LVEF in the control group was higher than that in the observation group (P<0.05). There were no obvious adverse reactions in the two groups. Conclusion Clopidogrel combined with rosuvastatin in the treatment of CHD can increase curative effect, improve vascular endothelial function and cardiac function, accelerate patients’ recovery, with higher safety. Key words: Coronary heart disease; Clopidogrel; Rosuvastatin; Vascular endothelial function; Cardiac function