Abstract
Despite the fact that the annual consumption of cigarets by the American public has been continually increasing, little substantial scientific research on the effect of cigaret smoke on the upper respiratory tract of normal persons has been recorded in the medical literature. Recently, the role of the hygroscopic agent—glycerin or diethylene glycol—in irritation of the respiratory tract has received some interest. Various approaches to the problem have been used in the published reports. Mulinos and Osborne 1 and Haag 2 studied the edema-producing properties of smoke solutions in the conjunctival sacs of rabbits. Flinn 3 and Ballenger and Johnson 4 made clinical observations on irritation of the pharyngeal mucous membranes. Holck and Carlson 5 used the salivary response as their index of irritation. All these investigators used glycerin-treated cigarets and diethylene glycol-treated cigarets. EXPERIMENTAL INVESTIGATION In this study I have utilized a silver-silver chloride glass electrode in conjunction with the Coleman electrometer for the purpose
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