Abstract
The acute oral LD 50 of the product in rats was found to be 2.28 ml/kg with limits of error of 87–117.5%. Subacute oral toxicity data have been presented. Two groups of rats fed at levels of 0.125 and 0.400 ml/kg for a 4-week period displayed no deleterious effects as compared to control animals. Hematologic and histologic studies revealed no abnormalities at the above levels. A group at a higher level, 1.25 ml/kg, exhibited 70% mortality during the experimental period and subnormal weight gains and food consumption. Micropathology on the latter group revealed slight to pronounced gastrointestinal damage. The undiluted preparation upon the intact and abraded skin of rabbits was found to be a moderate irritant with a primary irritation index of 5.08. A 1:80,000 aqueous dilution produced no irritation upon the intact and abraded skin of rabbits. A 1:80,000 aqueous dilution produced no ocular irritation when instilled into the conjunctival sac of rabbits.
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