Abstract
Chlorogenic acid (CGA), a phenolic acid compound found in a variety of natural plants, has strong antioxidant capacity. In this study, we aimed to investigate the effects of CGA on differentiation and lipid metabolism of 3T3-L1 cells, as well as its protective effect against cellular oxidative stress induced by H2O2. We found that CGA can reduce the accumulation of intracellular ROS and attenuate the production of inflammatory cytokines TNF-α under oxidative stress. CGA treatment significantly inhibited preadipocytes differentiation and lipid accumulation in 3T3-L1 cells. Our results suggest that CGA may regulate lipid metabolism by reducing the expression of differentiation-related genes and inhibiting triacylglyceride synthesis. The findings of this study support CGA as a potential therapeutic agent for obesity. The effects of CGA and its metabolites in vivo should be investigated to further support its application in functional foods.
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