Abstract
The utility of synthesized albumin microspheres containing mitomycin C (MMC), as a chemoembolization material against liver tumors in rats was evaluated. By observing angiograms of tumorous and normal rat livers with a soft X-ray apparatus, it was found that the blood flow in target site (tumor site) could be obstructed by infusion of albumin microspheres into the blood vessels of the liver. Furthermore, histological observations demonstrated that the blood vessels of target sites in the liver were embolized by albumin microspheres containing MMC and that parenchymal cells of the liver around the interlobular connective tissue were necrosed by MMC released from the infused albumin microspheres. The antitumor effects of albumin microspheres containing MMC on AH 272 liver metastasis were noticeably increased by intra-arterial administration compared to control (saline infusion) and free MMC. These results suggest that albumin microspheres containing MMC may be very useful as a material for chemoembolization.
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