Abstract
In oral sciences, chitosan application is of interest due to its antimicrobial and hemostatic activity. Chitosan coating of dentures and other intraoral devices could be beneficial for treatment of denture stomatitis or in the management of postoperative bleeding. Disinfection of dentures and prosthodontic materials is crucial before their use in patients. This study investigated the influence of chemical disinfectants on chitosan-coated surfaces. A total of 100 specimens were made: 50 of PMMA (polymethyl methacrylate), and 50 of PETG (polyethylene terephthalate glycol-modified) material and coated with 2% chitosan acetate solution. In each material, 5 groups (10 specimens each) were established and disinfected with Printosept-ID (L1), MD 520 (L2), Silosept (L3), or Dentavon (L4), or stored in distilled water (L0, control group). After disinfection, all specimens underwent abrasion tests (30,000 cycles in a tooth-brushing simulator). Areas without chitosan coating were measured by digital planimetry both before and after the disinfection/abrasion procedure and a damage-score was calculated. Regarding chitosan coating, the statistical analysis showed a significant influence of the disinfectants tested and significant differences between disinfectants (p < 0.05). Chitosan coating was most stable on PMMA and PETG after disinfection with MD 520 (L2). Otherwise, active oxygen containing disinfectants (L3, L4) led to the greatest alterations in the chitosan coating.
Highlights
The biopolymer chitosan (CS, Figure 1) [a (1→4) 2-amino-2-deoxy-β-D-glucan] is a semi-synthetic aminopolysaccharide derived from chitin by N-deacetylation [1,2,3]
The properties and activities of CS depend on many factors, for example, molecular weight (MW), degree of polymerization (DP), degree of deacetylation (DDA), environmental effects, and so on [12]
This study investigated the influence of chemical disinfection of CS coated polymethyl methacrylate (PMMA) and PETG
Summary
The biopolymer chitosan (CS, Figure 1) [a (1→4) 2-amino-2-deoxy-β-D-glucan] is a semi-synthetic aminopolysaccharide derived from chitin by N-deacetylation [1,2,3]. Chitin is, after cellulose, the second most common biopolymer and it is synthetized by a wide range of species, for example crustaceans, insects and fungi [1,2,4]. CS is known to be non-toxic, biocompatible and biodegradable; it shows a range of beneficial biological activities, among others, as an antimicrobial and hemostatic agent, in wound healing or tissue engineering [1,5,6,7,8,9,10,11,12]. The properties and activities of CS depend on many factors, for example, molecular weight (MW), degree of polymerization (DP), degree of deacetylation (DDA), environmental effects, and so on [12]
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