Abstract
Abstract A modification of the Allen protamine titration procedure is described, utilizing siliconized glassware, a smaller quantity of blood, and a constant volume of protamine solution. This modification is demonstrated to be sensitive and consistent. Its use, heretofore restricted to the investigation of hemorrhagic phenomena, permits the demonstration of constant variations during certain simple metabolic experiments. Certain nonmorbid physiological processes, particularly involving carbohydrate metabolism, appear to exert a marked influence on the human clotting mechanism. The changes are suggestive of those involving endogenous heparin or heparin-like material in the blood, but the mechanism of production of such material cannot yet. be explained.
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