Effect of center-based or home-based resistance training on muscle strength and VO2 peak in patients with HFrEF: A systematic review and meta-analysis.

Abstract

To analyze the components of resistance training (RT) exercises and evaluate the effects of RT on improving muscle strength and oxygen consumption (VO2) peak based on either center-based rehabilitation or home-based rehabilitation in patients with heart failure with reduced ejection fraction (HFrEF). According to the PRISMA guidelines, articles were searched through five databases, including Embase, MEDLINE, CINAHL, PEDro and Cochrane. RevMan 5.3 software was used to perform the meta-analysis. Nine randomized controlled trial studies met the study criteria, including a total of 299 respondents. In the center-based respondents (n=81 for intervention group vs. n=81 for control group), RT resulted in significant effects on both muscle strength of lower extremity (SDM=1.46, 95% CI=0.41-2.50, n=151) and upper extremity (SDM=0.46, 95% CI=0.05-0.87, n=97) and VO2 peak (MD=1.45ml/kg/min, 95% CI=0.01-2.89, n=114). In the home-based respondents (n=71 for intervention group vs. n=66 for control group), RT resulted in significant effects on muscle strength of both lower extremity (SDM=0.58, 95% CI: 0.20-0.97, n=113) and upper extremity (SDM=0.84, 95% CI: 0.24-1.44, n=47) and VO2 peak (MD=5.43ml/kg/min, 95% CI: 0.23-10.62, n=89). The RT exercise could increase muscle strength and VO2 peak at either center-based or home-based rehabilitation and should be considered as a part of the care of patients with HFrEF.