Effect of cefazolin sodium pentahydrate combined with azithromycin on CRP, PA, and PCT in children with acute respiratory tract infection

Abstract

Objective To investigate the clinical effect of cefazolin sodium pentahydrate combined with azithromycin in treating children with acute respiratory tract infection. Methods 102 children with acute respiratory tract infection were randomly divided into two groups in our hospital from February 2015 to December 2017. The control group was treated with cefazolin sodium pentahydrate, the observation group was treated with cefazolin sodium pentahydrate and azithromycin. C-reaction protein (CRP), pre-albumin (PA), procalcitonin (PCT), symptoms disappearance time, adverse reactions were compared between the two groups. Results Before treatment, there were no statistically significant differences in the levels of CRP, PA, PCT between the two groups (P>0.05); after treatment, the levels of CRP and PCT in the observation group were lower than those in the control group, the level of PA was higher than that in the control group, with statistically significant differences (P<0.05). The time of shortness of breath, fever, cough, lung rale disappearance in the observation group were shorter than those in the control group (P<0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (1.96% vs.15.69%), with statistically significant difference (P<0.05). Conclusion Cefazolin sodium pentahydrate combined with azithromycin in the treatment of children with acute respiratory tract infection can effectively alleviate clinical symptoms, helps to alleviate inflammatory reactions, with relatively fewer adverse reactions. Key words: Acute respiratory tract infection in children; Cefazolin sodium pentahydrate; Azithromycin; CRP; PA; PCT