Abstract
The purpose of this study was to evaluate the beneficial effects of Daucus carota root juice on carbon tetrachloride (CCl4) intoxicated rabbits. In this study, fifteen rabbits divided into 3 groups... The first group (G1) served as the control, the second group (G2) was treated with CCl4 , and a third group (G3) was treated with CCl4 +extract of Dacus Carota roots . Carbon tetrachloride alone caused a non-significant (P<0.05) increase in WBCs, RBCs, Hb and HCT compared with G1. and non-significant decrease in PLT was observed in CCl4 treated group compared with G1. Administration of Daucus carota roots juice to CCl4 G3 shown a significant (P<0.05) increase in the HCT, WBCs, PLT and non- significant change in RBCs and Hb.
Highlights
Carbon tetrachloride (CCl4) is largely used as a solvent in many industries, CCl4 is frequently used to induce oxidative stress in experimental animals ( Shyu,2008)
The purpose of this study was to evaluate the beneficial effects of Daucus carota root juice on carbon tetrachloride (CCl4) intoxicated rabbits
Lungs ( Khan et al .,2010; Sahreen et al ., 2014 ) heart ( Sahreen et al ., 2013 ) testes ( Ahmad et al, 1987) and blood ( Abraham etal., 1999) . the kidney has a higher affinity to CCl4 than liver( Ronis et al ., 1988) due to the predominance of cytochrome P-450 in the renal cortex ( Khan et al ., 2009)
Summary
Carbon tetrachloride (CCl4) is largely used as a solvent in many industries, CCl4 is frequently used to induce oxidative stress in experimental animals ( Shyu ,2008). The kidney has a higher affinity to CCl4 than liver( Ronis et al ., 1988) due to the predominance of cytochrome P-450 in the renal cortex ( Khan et al ., 2009). Many studies in vitro and vivo demonstrated that CCl4 can decrease the ratio of renal reduction/oxidized glutathione, microsomes and mitochondria while inducing an increase in lipid peroxidise in kidney ( Adewle et al ., 2007 ; Maran et al ., 1991 ). Daucus carota commonly known as carrot is one of the most important vegetables belonging to family Apiecea I an annual or biannual herb mostly confined to the temperate regions of Europe , Asia and Africa,its active ingredients including volatile oils , steroids , tannis flavonoids, and carotene have been isolated ( Jasicka etal .,2005; Vasudevan etal., 2006; Yu ll etal., 2005) carrot seeds are rich with antioxidants ( Fuhraman et al ., 2000) .
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