EFFECT OF CAMELS MILK FEEDING ON OXIDATIVE STRESSES IN EXPERIMENTALLY INDUCED DIABETIC RABBITS

Abstract

Diabetes mellitus is a multi-factorial disorder that CHARacterized by hyperglycemia, lipoprotein abnormalities resulting from malfunction in insulin secretion and/or insulin action causing impaired metabolism of glucose, lipids and protein. In addition, generation of free radicals often worsen the complications of diabetes mellitus such as hypertension, atherosclerosis and microcirculatory disorders. A group of scientists reported the effect of camel milk on diabetes, referring to its importance in treatment of diabetes and patients who drink camel milk daily, their need to insulin decrease. Therefore, this study aimed to throw light on the effect of camel milk in comparison to insulin treatment. This study was carried out on forty male New Zealand rabbits, divided into four equal groups each group contained ten rabbits. The first group (G1) was considered as control non diabetic group injected with normal saline solution. The other animals were injected intravenously with alloxan for induction of experimental diabetes mellitus and then divided into three equal groups ten rabbits each as the follows: (G2) considered as control diabetic left untreated, (G3) was considered as diabetic insulin treated group, (G4) was considered as diabetic camel milk treated group. After the end of the experiment (4 weeks), blood (whole blood & serum) in addition to tissue samples (liver, kidney and pancreas) were collected from all the animals for analysis of: enzymatic SOD and catalase, non-enzymatic GSH antioxidant enzyme activities. Serum malondialdeyde, glucose, insulin and lipid profile.It was observed that the effect of camel milk containing insulin like peptides, vitamin C and zinc in addition to other minerals and vitamins that are effective in the treatment of diabetes in comparison to insulin treatment alone. In addition to its hypoglycemic effect and improvement of oxidative stress accompanied with diabetes mellitus.It was observed that there is regeneration in  cells and S.Sherbini. et.al., 76 high number of islets of Langerhans among the pancreatic acini in rabbits receiving camel milk. There is a wide similarity between camel milk and goat milk. So, from this study, camel milk administration in case of insulin dependant diabetes mellitus is recommended as oral anti diabetic drug. ,