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Abstract
INTRODUCTIONLATHYRISM induced in the developing chick embryo has been shown by Levene and Gross (1959) to increase fragility of collagen containing tissues and to increase the solubility of collagen in cold neutral saline. Skeletal and vascular lesions associated with this condition can largely be attributed to inadequate formation or breakdown of the collagen containing tissues. Smiley et al. (1962) administered proline-C14 to normal chick embryos and to embryos rendered lathyritic by beta-aminopropionitrile. Increased amounts of extractible collagen from lathyritic embryos exhibited higher hydroxyproline specific activity than did collagen from normal embryos. Residue collagen in treated embryos had a lower hydroxyproline specific activity than did residue collagen from normal embryos. Their (Smiley et al., 1962) results suggest that the increased amount of soluble collagen in lathyrism induced by beta-aminopropionitrile is largely due to a blockage in the formation of mature insoluble collagen fibrils. Through prior labeling of the insoluble collagen,…
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