Abstract
Effect of caffeine on some selected biochemical parameters using rat model was investigated. Standard methods of analysis were used for the study. A total of sixty (60) rats divided equally into five groups of which one group served as the control, and the rest as test groups were used. The test rats were placed on different concentrations of caffeine for twenty-eight (28) days. Results obtained for the selected biochemical parameters revealed that AST and ALT levels of the liver increased significantly (p<0.05) in test rats against the control. Creatinine and electrolyte ions of the kidney increased significantly (p<0.05) in test groups when compared to the control. Haematological indices such as WBC, monocytes, lymphocytes, MCV, MCHC, and MCV levels were significantly altered (p<0.05) in test rats against those of the control. It therefore becomes imperative for those that consume caffeine with believe that it does more good work than harm to take note of these findings. This study has revealed the effect of caffeine on some selected biochemical parameters using rat model.
Highlights
It is on record that so many bioactive compounds found in plants have been useful to both plants and animals [1,2,3,4,5,6,7,8]
A total of sixty (60) male albino rats of Wistar strain weighing between 100 and 130 g were purchased from animal colony of the Department of Biochemistry, Abia State University, Uturu, Nigeria, and kept in standard cages for 7 days to enable them acclimatize to their new environment
The increased transaminase levels of test rats against the control as observed in the present study could be linked to consumption of caffeine
Summary
It is on record that so many bioactive compounds found in plants have been useful to both plants and animals [1,2,3,4,5,6,7,8] Some of these useful compounds have been industrially synthesized and used in different ways to meet up with the supposed effects of the natural form of the compounds in living organisms. Records have it that the productions of most consumable products are done with the naturally extracted products of these compounds or their synthetic analogue. The present study aimed at setting aside the controversies surrounding the toxicity of caffeine in living organism and investigated its effect on some selected biochemical parameters using rat model
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