Abstract
The aim of the study was to examine the effect of caffeine on the diffusion of two pain-relieving drugs, namely paracetamol and sodium salicylate, in aqueous solutions at a temperature of 25.00ºC, using the Taylor dispersion method to determine the mutual diffusion coefficients for these ternary aqueous solutions. Ternary mutual diffusion coefficients are reported for aqueous solutions of paracetamol + caffeine, and sodium salicylate + caffeine, at 25.00ºC, and concentrations up to 0.050mol·dm-3. The data indicate that the presence of caffeine affects the diffusion of analgesic drugs. For example, a coupled diffusion of these drugs with caffeine was observed through the non-zero values of the cross-diffusion coefficients. Support for this came from the good agreement between our data and the predicted by a model of the diffusion that includes 1:1 complex, being obtained the association constants for systems [(caffeine and paracetamol) and (caffeine and salicylate sodium)], K=70mol-1·dm3 and K=80, respectively. These data provide us with a better understanding of the mechanisms of mass transport through diffusion in biological systems, as well as the structure of these systems.
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