Effect of caffeic acid on radiotherapy-induced hypocytosis in patients with lung cancer

Abstract

Objective To investigate the clinical effect of caffeic acid tablets on hypocytosis induced by radiotherapy in patients with lung cancer. Methods From January 2017 to October 2015, one hundred and twenty patients with lung cancer treated by radiotherapy in No.88 Hospital of PLA were selected and randomly divided into the observation group and the control group, 60 cases in each group.Patients in the observation group were treated by oral caffeic acid tablets 0.3 g/time, 3 times/d until the end of radiotherapy.The control group was treated with radiotherapy alone and did not take any blood raising drugs.When myelosuppression appeared, recombinant human granulocyte colony-stimulating factor Injection or recombinant human interleukin 11 was given till it turned to normal blood.The incidence rate of bone marrow suppression, number of white blood cells(WBC), platelet (PLT) and the efficacy of radiotherapy were observed. Results The incidence rate of bone marrow suppression of the observation group was 16.67%(10/60), which was significantly lower than that of the control group(63.33%(38/60)). The difference was statistically significant (χ2=27.22, P 0.05). Conclusion Caffeic acid tablet is effective in preventing leukocyte and thrombocytopenia caused by bone marrow suppression in patients with lung cancer after radiotherapy. Key words: Caffeic acid; Lung cancer; Radiotherapy; Leukocyte reduction; Thrombocytopenia