Effect of caffeic acid on chemotherapy-induced hypocytosis in patients with B-cell non-Hondgkin’s lymphoma

Abstract

Objective To investigate the clinical effect of caffeic acid tablets on hypocytosis induced by R-CHOP regimen chemotherapy on patients with B-cell non-Hondgkin’s lymphoma. Methods Eighty-two patients with B-cell non-Hondgkin lymphoma were randomly divided into two groups, with 41 patients in each group. Each patient received R-CHOP regimen chemotherapy for 2 courses, and each course lasted for 21 days. The patients in the observation group were treated by oral caffeic acid tablets 0.3 g/time, 3 times/d, until the 14th day after chemotherapy. And the patients in the control group were treated by chemotherapy only. The number of white blood cells (WBC), platelet (PLT), the incidence rate of bone marrow suppression, and the incidence of infection, hemorrhage were observed. Results The number of WBC, PLT at the 7th day, 14th day and 21th day after chemotherapy was significantly higher in the observation group than those of the control group(P<0.05). The incidence of bone marrow suppression of the observation group was 29.27%, which was significantly lower than that of the control group (60.98%, P<0.05). The incidence of infection in the observation group was 24.39%, which was significantly lower than that of the control group (56.09%, P<0.05). The incidence of hemorrhage in the observation group was 14.63%, which was significantly lower than that of the control group (36.59%, P<0.05). Conclusions Caffeic acid can effectively prevent and treat leukopenia and thrombocytopenia induced by chemotherapy in patients with B-cell non-Hondgkin’s lymphoma. Key words: Caffeic acid; Non-Hondgkin’s lymphoma; Chemotherapy; Leukopenia; Thrombocytopenia