Abstract
：Objective To evaluatethe effects of physiological doses of C-peptide on islet microcirculation,bloodglucose,and insulin concentrations.Methods Adult male Wistar rats were divided into twogroups i.v either with C-peptide (75nmoL/kg body wt)or saline (control).Each group wasfurther divided into 2 subgroups using 1 ml saline or 30% glucose.A microsphere techniquewas adopted to measure the pancreatic islet microcirculation.Results Intravenous injectionof C-peptide markedly increased basal islet blood flow[(0.156±flow[(14.33±0.53 vs 9.16±0.64)%,P＜0.01],but did not affect islet microcircuJation after intravenousglucose administration.In IPGT,C-peptide decreased blood glucose at 30 min[(7.9±0.7 vs11.5±0.6) mmol/L,P＜0.01]after glucose challenge and stimulated insulinsecretion(for AUCins(0.120),141.36±15.00 vs 49.78±5.60,P ＜0.01).Conclusion C-peptide inducesredistribution of pancreatic blood flow in favour of islet in normoglycemic rats,andmodulates insulin release in hyperglycaemic rats. Key words: C-peptide; Microshpere technique; Isletmicrocircolation; Intraperitoneal glucose tolerance test
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