Effect of budesonide on lung function and inflammatory factors levels in elderly patients with acute attack of COPD

Abstract

Objective To analyze the effects of budesonide on pulmonary function and inflammatory factors in elderly patients with acute attack stage of chronic obstructive pulmonary disease (COPD). Methods Eighty-nine hospitalized patients with acute attack stage of COPD from September 2015 to November 2016 were randomly divided into two groups, the 44 cases in the control group were treated by conventional treatment, and the 45 cases in the observation group were treated by conventional treatment combined with budesonide inhalation therapy, the levels of lung function, interleukin-6(IL-6), interleukin-10(IL-10), tumor necrosis factor (TNF-α) and C-reactive protein (CRP) after treatment were compared between the two groups. Results After treatment, the FVC, FEV1 and IL-10 in the observation group were significantly higher than those in the control group, and the levels of inflammatory factors IL-6, TNF-α, and CRP were significantly lower than those in the control group (P<0.05). Conclusions Routine treatment combined with budesonide can effectively ameliorate the level of inflammatory factors in patients with acute exacerbation of COPD, and promote the recovery of lung function, so it is effective and worthy of clinical promotion. Key words: Budesonide; Chronic obstructive pulmonary disease; Acute attack stage; Pulmonary function; Inflammatory factors